Why is nicotinamide mononucleotide so popular among R&D supplement and cosmetics companies? Why you should know nicotinamide mononucleotide? It is all about aging. Searching for a means of preventing the ageing process, and prolong lifespan to longevity has been hopes of humans all over the world for decades. But now it’s on the way to becoming real truth as Australian and American scientists believe they’ve found a compound of not just ‘pausing’ the ageing process but ‘reversing’ it!The chemical structure of nicotinamide mononucleotide is as below:
Here are some data for you to know this amazing NMN ingredient. An experiment made by Harvard scientist professor David Sinclair who has previously been behind research that found reservatol a substance found in red wine and certain nuts, made an anti-ageing gene SIRT1 run faster.
This new compound, NMN, activates all seven of the sirtuin genes implicated in longevity. Biological aging had been reversed in just one week by injecting NMN ingredient to mice. A 22-month old mouse reverted back to a more youthful state in just one week, equivalent to turning a 60-year old human back to being 20 again. NMN supplements are Much more powerful than resveratrol, pterostilbene, NR, or whatever or anti-aging creams on the planet.
NMN, a precursor of NAD+ (nicotinamide adenine nucleotide) and NADH biosynthesis, is a novel anti-aging and lifespan-prolonging ingredient, and you may not hear about it before, but you may know NIAGEN or Nicotinamide Riboside (NR) marketed by Chromadex Inc. However, Nicotinamide mononucleotide should not be confused with nicotinamide riboside (NR), and other NAD related substances already on the market even though they may share certain properties, particularly at a genetic level; NMN is significantly more powerful than Nicotinamide Riboside. For the time being, there is no bulk commercial quantity of Nicotinamide mononucleotide available on the market, but keep in mind that, Herb Nutritionals Co., Ltd is to enlarge its capacity to commercial quantity within three months.
Nicotinamide mononucleotide VS Nicotinamide Riboside
Both Nicotinamide Riboside and nicotinamide mononucleotide are NAD+ precursor, and able to increase the NAD+ level. The likely mechanism of nicotinamide mononucleotide uptake is extracellular conversion to nicotinamide riboside (NR). In addition, NMN is more powerful than NR in its anti-aging effects. Of course, the price of NMN is much more expensive.
Nicotinamide mononucleotide and NAD
Since NAD+ cannot be given directly to the mice because of its toxic effects (serious hyperglycemia lasting for hours), the researchers used NMN instead, which resulted in the increase of NAD production in the mice. In the meanwhile, nicotinamide mononucleotide was immediately utilized and converted to NAD+ within 15 mins in the body, and also convert to NR as well.
β-NMN is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.
Found in all living cells, NAD+ is a coenzyme involved in redox reactions. It consists of two nucleotides linked by their phosphate group. One nucleotide contains an adenine, the other a nicotinamide. It helps enzymes transfer electrons during redox reactions to form ATP and is thus an aid to energy supply. However, levels decline with age – the NAD+ in an older person’s cells will have fallen by more than 50%. The mitochondria then produce less energy and cells age. Fortunately, this process is not irreversible and intercellular energy mechanisms can be restored if levels of NAD+ are increased.
In addition, NAD is an essential cofactor of key longevity enzymes called sirtuins, activating them directly. Sirtuins play a fundamental role in life expectancy as they deactivate particular genes that lead to ageing via inflammatory processes.
Thus the combined fall in sirtuins 1 and 3, and in NAD+, can cause cerebral degeneration, vascular inflammation, fatigue, loss of muscle strength, increased fat stores around the liver and abdomen and insulin resistance leading directly to metabolic syndrome.
All of these processes can be reversed by means of calorie restriction or supplementation with nicotinamide mononucleotide.
Nicotinamide mononucleotide food sources
nicotinamide mononucleotide is a rare compound and may not able to find in natural foods, but is naturally occurring in the body that plays a vital role in how cells use energy. It is involved in the synthesis of nicotinamide adenine dinucleotide (NAD), a coenzyme in cells that is essential for converting energy from nutrients into a form cells can use. NMN increases NAD which in turn activates a protein called SIRT1 to promote healthy metabolism throughout the body, particularly from the pancreas to the liver, and to muscles and fat tissue.
Mechanism of action of nicotinamide mononucleotideHow does nicotinamide mononucleotide work? The answer may be simple: NMN increase the NAD+ level in the body. Then, all the modes of acts of NMN is to be the mechanism of NAD+. β-Nicotinamide mononucleotide is a key NAD+ intermediate. It restores NAD+ levels in HFD-induced T2D mice ameliorating glucose intolerance. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
Benefits of taking nicotinamide mononucleotide supplements
NMN is proved by Harvard scientists to reverse aging process and may be new alternatives to aging, type II diabetes, cancers, muscle wasting and inflammatory diseases within five to ten years. Many supplements are ordering raw ingredients from us to try it in their new anti-aging products. The cost is the main concern to commercialize NMN.
Nicotinamide mononucleotide will not only help prolong lifespan but has additionally proven promise in dealing with diabetes type 2. This degenerative disease is directly associated with over-use of body fat and calories which overwhelm adaptive metabolic paths. Mouse studies demonstrated that NMN enhanced glucose tolerance by restoring NAD levels. It enhanced blood insulin sensitivity within the liver, restored impaired gene expression associated with oxidative stress, inflammatory response and also the circadian rhythm by initiating SIRT1.
There has been very little research conducted on human, and adverse effects of NMN is not known. Always conduct your doctor before taking NMN supplements.
Dosage of nicotinamide mononucleotide
There are yet no supplements of nicotinamide mononucleotide on the market, and recommended dose for NMN is not available. However, scientific studies show that 30g to 50g nicotinamide mononucleotide powder each day is necessary to achieve the same anti-aging effect as that of the mice experiment. We know that the recommended dosing of Nicotinamide Riboside supplementing is 250mg per serving in capsule form, and twice a day. Therefore, the dosage for NMN is less than that since NMN is more powerful than NR in this anti-aging aspect.